Electrochemical Investigation of Tamoxifen Effect on DNA at the Presence of an Antioxidant

Cancer is described as the uncontrollably multiplying abnormal proliferation of cells. can affect everyone, and risk which rises with age, lifestyle, environmental toxins. Tamoxi̇fen (TAM) a selective estrogen receptor modulator, has estrogenic or antiestrogenic effects on breast tissue by binding to receptors. The current study presents voltammetric biosensor identify effect Tamoxifen DNA structure. In this study, TAM double-stranded (dsDNA) was investigated electrochemically in both presence absence antioxidants. For purpose, TAM-dsDNA-antioxidant interaction using pencil graphite electrode (PGE). modified sensor created simply wet-adsorbtion method. prepared examined square wave voltammety (SWV) method, its lowest concentration optimum pH range were determined. dsDNA simultaneously for first time literature.